A Case of Exophytic Pilomatricoma Clinically Resembling Keratoacanthoma

258 Ann Dermatol Received January 27, 2016, Revised April 8, 2016, Accepted for publication May 11, 2016 Corresponding author: Il-Hwan Kim, Department of Dermatology, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan 15355, Korea. Tel: 82-31-412-5186, Fax: 82-31-412-4208, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology of melanocyte and melanin pigment was observed. A traditional histologic feature of vitiligo is epidermal loss of melanocytes, but a recent research by Kim et al. imply that residual melanocytes, although in lower level, may exist in vitiligo lesion. Unfortunately the relationship between the amount of residual melanocyte and degree of repigmentation is not yet established. Secondly, the vitiligo lesion showed complete pigmentation after treatment. Vitiligo itself is not an incurable disease, but all the reports of vitiligo with concomitant AN have failed to induce repigmentation. In conclusion, when AN is accompanied by hypopigmentation assessing the amount of melanocyte by means of skin biopsy can be helpful in predicting the potential degree of repigmentation after vitiligo treatment. This finding does not seem to affect the course of AN and thus treatment of underlying cause of AN would still be required.